Ivermectin 12mg is a broad-spectrum antiparasitic medication that has been widely used for several decades. The 12 mg dosage of Ivermectin is commonly prescribed to treat various parasitic infections in humans. Below is an overview of the uses, mechanisms, and considerations for using Buy Ivermectin Online.
Primary Uses of Ivermectin 12 mg Tablet
- Treatment of Parasitic Infections:
- Onchocerciasis (River Blindness): Ivermectin is particularly effective against Onchocerca volvulus, the parasitic worm responsible for river blindness. It works by killing the larvae (microfilariae) of the worm, which helps to reduce the symptoms and transmission of the disease.
- Strongyloidiasis: This is a parasitic infection caused by the roundworm Strongyloides stercoralis. Ivermectin helps to eliminate the adult worms and prevent the spread of the infection in the body.
- Scabies: Ivermectin is also used to treat scabies, a skin condition caused by the Sarcoptes scabiei mite. The drug kills the mites and their eggs, relieving the itching and discomfort associated with scabies.
- Lymphatic Filariasis: Ivermectin, often in combination with other medications like albendazole, is used to treat lymphatic filariasis, a mosquito-borne disease caused by filarial worms. It helps reduce the number of microfilariae in the blood, thus preventing the spread of the disease to others.
- Other Parasitic Infections: Ivermectin is sometimes used off-label for other parasitic infections, such as head lice, depending on the clinical scenario.
Mechanism of Action
Ivermectin works by binding to certain ion channels in the nerve and muscle cells of parasites, leading to increased permeability of the cell membrane to chloride ions. This results in paralysis and death of the parasite. However, it does not typically kill adult worms in certain infections, such as Onchocerciasis, but it does significantly reduce the burden of infection by eliminating the microfilariae.
Dosage and Administration
- Typical Dosage: The standard dose of Ivermectin for treating most parasitic infections is based on the patient’s weight, typically 150-200 mcg/kg. For the 12 mg tablet, the exact dosage will be determined by the healthcare provider based on the specific infection being treated and the patient’s body weight.
- Administration: Ivermectin is usually taken as a single dose on an empty stomach with water. In some cases, particularly with strongyloidiasis or scabies, additional doses may be required, typically after a few days or weeks.
Precautions and Considerations
- Contraindications: Ivermectin should be used with caution in patients with certain conditions, such as liver disease or in those taking medications that can interact with Ivermectin. It is contraindicated in individuals allergic to Ivermectin or any of its components.
- Pregnancy and Breastfeeding: Ivermectin should only be used during pregnancy if the potential benefits outweigh the risks. Breastfeeding women should consult their healthcare provider before taking Ivermectin, as the drug can be passed through breast milk.
- Side Effects: Common side effects of Ivermectin include nausea, dizziness, diarrhea, and fatigue. In the treatment of parasitic infections like Onchocerciasis, patients may experience an inflammatory reaction known as the Mazzotti reaction, characterized by fever, skin rash, and swelling, due to the rapid killing of microfilariae.
- Drug Interactions: Ivermectin may interact with other medications, particularly those that affect the liver enzymes involved in drug metabolism. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
COVID-19 and Ivermectin
Ivermectin gained attention during the COVID-19 pandemic as a potential treatment option. However, the use of Ivermectin for COVID-19 is controversial and not widely recommended by health authorities, such as the World Health Organization (WHO) and the U.S. Food and Drug Administration (FDA). Most studies have shown insufficient evidence to support its efficacy against COVID-19, and self-medication or misuse of Ivermectin for this purpose is strongly discouraged.
Conclusion
Ivermectin 12 mg tablets are an effective treatment for a variety of parasitic infections. It is essential to use this medication under the guidance of a healthcare provider to ensure its safe and appropriate use. While it is a well-established drug for conditions like river blindness, strongyloidiasis, and scabies, it is important to adhere strictly to prescribed dosages and be aware of potential side effects and interactions.